SCOPe 2.08: Domain d6di9a_: 6di9 A:

Lineage for d6di9a_ (6di9 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d6di9a_: 6di9 A: [357161]
   automated match to d5p9ia_
   complexed with dms, gjj

Details for d6di9a_

PDB Entry: 6di9, 1.25 Å

PDB Description: crystal structure of btk in complex with covalent inhibitor

PDB Compounds: (A:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d6di9a_:

Sequence, based on SEQRES records:

>d6di9a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmn
lsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceamey
leskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmy
skfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimy
scwhekaderptfkillsnildvmdees

Sequence, based on observed residues (ATOM records):

>d6di9a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ygsweidpkdltflkelvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshekl
vqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyleskqf
lhrdlaarnclvndqgvvkvsdfglsryvlkfpvrwsppevlmyskfssksdiwafgvlm
weiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwhekaderptfkil
lsnildvmdees

Timeline for d6di9a_:

• d6di9a_ first appeared in SCOPe 2.07