SCOPe 2.08: Domain d6efgb1: 6efg B:2-181

Lineage for d6efgb1 (6efg B:2-181)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.0: automated matches [227300] (1 protein)
   not a true family

6. Protein automated matches [227126] (21 species)
   not a true protein

7. Species Kluyveromyces lactis [TaxId:284590] [356722] (2 PDB entries)

8. Domain d6efgb1: 6efg B:2-181 [356967]
   Other proteins in same PDB: d6efga2, d6efgb2, d6efgd2, d6efge2
   automated match to d2vk4a1
   complexed with mg, tpp

Details for d6efgb1

PDB Entry: 6efg, 2.04 Å

PDB Description: pyruvate decarboxylase from kluyveromyces lactis

PDB Compounds: (B:) pyruvate decarboxylase

SCOPe Domain Sequences for d6efgb1:

Sequence, based on SEQRES records:

>d6efgb1 c.36.1.0 (B:2-181) automated matches {Kluyveromyces lactis [TaxId: 284590]}
seitlgrylferlkqvevqtifglpgdfnlslldniyevpgmrwagnanelnaayaadgy
arlkgmsciittfgvgelsalngiagsyaehvgvlhvvgvpsvssqakqlllhhtlgngd
ftvfhrmssnisettamitdintapaeidrcirttyvsqrpvylglpanlvdltvpasll

Sequence, based on observed residues (ATOM records):

>d6efgb1 c.36.1.0 (B:2-181) automated matches {Kluyveromyces lactis [TaxId: 284590]}
seitlgrylferlkqvevqtifglpgdfnlslldniyevpgmrwagnanelnaayaadgy
arlkgmsciittfgvgelsalngiagsyaehvgvlhvvgvpsvngdftvfhrmssniset
tamitdintapaeidrcirttyvsqrpvylglpanlvdltvpasll

Timeline for d6efgb1:

• d6efgb1 first appeared in SCOPe 2.07