SCOPe 2.08: Domain d5oo3a_: 5oo3 A:

Lineage for d5oo3a_ (5oo3 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d5oo3a_: 5oo3 A: [356896]
   automated match to d4fkla_
   complexed with 9zb

Details for d5oo3a_

PDB Entry: 5oo3, 1.73 Å

PDB Description: cdk2(f80c, c177a) with covalent ligand at f80c

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d5oo3a_:

Sequence, based on SEQRES records:

>d5oo3a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
enfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnhp
nivklldvihtenklylvceflhqdlkkfmdasaltgiplpliksylfqllqglafchsh
rvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgakyys
tavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfp
kwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

Sequence, based on observed residues (ATOM records):

>d5oo3a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
enfqkvekigegtygvvykarnkltgevvalkkirlpstaireisllkelnhpnivklld
vihtenklylvceflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdl
kpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgakyystavdiws
lgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdf
skvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

Timeline for d5oo3a_:

• d5oo3a_ first appeared in SCOPe 2.07