SCOPe 2.08: Domain d5nrqa_: 5nrq A:

Lineage for d5nrqa_ (5nrq A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Thymidylate kinase [52563] (5 species)

7. Species Mycobacterium tuberculosis [TaxId:83332] [346929] (5 PDB entries)

8. Domain d5nrqa_: 5nrq A: [355935]
   automated match to d1gsia_
   complexed with cl, zui

Details for d5nrqa_

PDB Entry: 5nrq, 2.1 Å

PDB Description: mtb tmk crystal structure in complex with compound 33

PDB Compounds: (A:) thymidylate kinase

SCOPe Domain Sequences for d5nrqa_:

Sequence, based on SEQRES records:

>d5nrqa_ c.37.1.1 (A:) Thymidylate kinase {Mycobacterium tuberculosis [TaxId: 83332]}
mliaiegvdgagkrtlveklsgafraagrsvatlafprygqsvaadiaaealhgehgdla
ssvyamatlfaldragavhtiqglcrgydvvildryvasnaaysaarlhenaagkaaawv
qriefarlglpkpdwqvllavsaelagersrgraqrdpgrardnyerdaelqqrtgavya
elaaqgwggrwlvvgadvdpgrlaatlap

Sequence, based on observed residues (ATOM records):

>d5nrqa_ c.37.1.1 (A:) Thymidylate kinase {Mycobacterium tuberculosis [TaxId: 83332]}
mliaiegvdgagkrtlveklsgafraagrsvatlafprygqsvaadiaaealhgehgdla
ssvyamatlfaldragavhtiqglcrgydvvildryvasnaaysaarlhenaagkaaawv
qriefarlglpkpdwqvllavsaelagedaelqqrtgavyaelaaqgwggrwlvvgadvd
pgrlaatlap

Timeline for d5nrqa_:

• d5nrqa_ first appeared in SCOPe 2.07