SCOPe 2.08: Domain d5y0zb_: 5y0z B:

Lineage for d5y0zb_ (5y0z B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein Sirt2 histone deacetylase [63987] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63988] (23 PDB entries)

8. Domain d5y0zb_: 5y0z B: [355266]
   automated match to d1j8fc_
   complexed with 8k9, zn

Details for d5y0zb_

PDB Entry: 5y0z, 2 Å

PDB Description: human sirt2 in complex with a specific inhibitor, npd11033

PDB Compounds: (B:) nad-dependent protein deacetylase sirtuin-2

SCOPe Domain Sequences for d5y0zb_:

Sequence, based on SEQRES records:

>d5y0zb_ c.31.1.5 (B:) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
kerlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpy
peaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtler
iagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivf
fgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagggg
mdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

Sequence, based on observed residues (ATOM records):

>d5y0zb_ c.31.1.5 (B:) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
kerlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpy
peaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtler
iagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivf
fgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagggm
dfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

Timeline for d5y0zb_:

• d5y0zb_ first appeared in SCOPe 2.07