SCOPe 2.08: Domain d6drwa1: 6drw A:840-1131

Lineage for d6drwa1 (6drw A:840-1131)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d6drwa1: 6drw A:840-1131 [354885]
   Other proteins in same PDB: d6drwa2
   automated match to d5j87b_
   complexed with ske

Details for d6drwa1

PDB Entry: 6drw, 2.3 Å

PDB Description: jak2 jh1 in complex with jnj-7706621 (crystal form 2)

PDB Compounds: (A:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d6drwa1:

Sequence, based on SEQRES records:

>d6drwa1 d.144.1.0 (A:840-1131) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma

Sequence, based on observed residues (ATOM records):

>d6drwa1 d.144.1.0 (A:840-1131) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptqfeerhlkflqqlgkfgsvemcrydplqdntgevvavkklqhsteehlrdfereiei
lkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqic
kgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkespifwyape
slteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellkn
ngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma

Timeline for d6drwa1:

• d6drwa1 first appeared in SCOPe 2.07