SCOPe 2.08: Domain d6fs7b1: 6fs7 B:1-198

Lineage for d6fs7b1 (6fs7 B:1-198)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.52: Restriction endonuclease-like [52979] (4 superfamilies)
   core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest

4. Superfamily c.52.1: Restriction endonuclease-like [52980] (37 families)

5. Family c.52.1.34: PA N-terminal domain [254166] (3 proteins)
   Pfam PF00603; relationship to endonucleases discussed in PubMed 19194458

6. Protein PA N-terminal domain [254375] (8 species)

7. Species Influenza A virus [TaxId:93838] [254808] (91 PDB entries)

8. Domain d6fs7b1: 6fs7 B:1-198 [354647]
   Other proteins in same PDB: d6fs7a2, d6fs7b2, d6fs7c2, d6fs7d2, d6fs7e2, d6fs7f2
   automated match to d4e5ea_
   complexed with e4z, mn; mutant

Details for d6fs7b1

PDB Entry: 6fs7, 1.96 Å

PDB Description: influenza a/california/04/2009 (ph1n1) endonuclease with i38t mutation with bound inhibitor, baloxavir acid (bxa)

PDB Compounds: (B:) Polymerase acidic protein,Polymerase acidic protein

SCOPe Domain Sequences for d6fs7b1:

Sequence, based on SEQRES records:

>d6fs7b1 c.52.1.34 (B:1-198) PA N-terminal domain {Influenza A virus [TaxId: 93838]}
medfvrqcfnpmivelaekamkeygedpkietnkfaatcthlevcfmysdfgsgdpnall
khrfeiiegrdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyyl
ekankiksekthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfr
qserge

Sequence, based on observed residues (ATOM records):

>d6fs7b1 c.52.1.34 (B:1-198) PA N-terminal domain {Influenza A virus [TaxId: 93838]}
medfvrqcfnpmivelaekamkeygedpkietnkfaatcthlevcfmysdkhrfeiiegr
drimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyylekankiksek
thihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqserge

Timeline for d6fs7b1:

• d6fs7b1 first appeared in SCOPe 2.07