SCOPe 2.08: Domain d6cjfa1: 6cjf A:33-396

Lineage for d6cjfa1 (6cjf A:33-396)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)

8. Domain d6cjfa1: 6cjf A:33-396 [352416]
   Other proteins in same PDB: d6cjfa2, d6cjfb2
   automated match to d3kvma_
   complexed with f54, fmn, oro, zwi
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d6cjfa1

PDB Entry: 6cjf, 1.63 Å

PDB Description: human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43

PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d6cjfa1:

Sequence, based on SEQRES records:

>d6cjfa1 c.1.4.1 (A:33-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr

Sequence, based on observed residues (ATOM records):

>d6cjfa1 c.1.4.1 (A:33-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllqdsdmlevrvlghkfrnpvgiaag
fdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsvv
ehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvgkae
lrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsr
paglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekirag
aslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

Timeline for d6cjfa1:

• d6cjfa1 first appeared in SCOPe 2.07