SCOPe 2.08: Domain d6f0ac_: 6f0a C:

Lineage for d6f0ac_ (6f0a C:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
   multihelical; bundle, contains interrupted helices

4. Superfamily a.266.1: Indolic compounds 2,3-dioxygenase-like [140959] (3 families)
   contains heme-dependent enzymes

5. Family a.266.1.2: Indoleamine 2,3-dioxygenase-like [140963] (3 proteins)
   Pfam PF01231; contains extra N-terminal all-alpha subdomain of similar fold to the GST C-terminal domain (47615)

6. Protein automated matches [190585] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187592] (52 PDB entries)

8. Domain d6f0ac_: 6f0a C: [350583]
   automated match to d4u72b_
   complexed with ala, c82, hem

Details for d6f0ac_

PDB Entry: 6f0a, 2.26 Å

PDB Description: crystal structure of human indoleamine 2,3-dioxygenase bound to a triazole inhibitor and alanine molecule.

PDB Compounds: (C:) Indoleamine 2,3-dioxygenase 1

SCOPe Domain Sequences for d6f0ac_:

Sequence, based on SEQRES records:

>d6f0ac_ a.266.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhl
tdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcv
lanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqm
qerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvye
gfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsl
esnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsed
pskleakgtggtdlmnflktvrstteksllke

Sequence, based on observed residues (ATOM records):

>d6f0ac_ a.266.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhl
tdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcv
lanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqm
qerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvye
gfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsl
esnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpleakgtgg
tdlmnflktvrstteksllke

Timeline for d6f0ac_:

• d6f0ac_ first appeared in SCOPe 2.07