SCOPe 2.08: Domain d6cadb1: 6cad B:449-705

Lineage for d6cadb1 (6cad B:449-705)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d6cadb1: 6cad B:449-705 [350340]
   Other proteins in same PDB: d6cada2, d6cadb2
   automated match to d4e26b_
   complexed with eu4

Details for d6cadb1

PDB Entry: 6cad, 2.55 Å

PDB Description: crystal structure of raf kinase domain bound to the inhibitor 2a

PDB Compounds: (B:) Serine/threonine-protein kinase B-raf

SCOPe Domain Sequences for d6cadb1:

Sequence, based on SEQRES records:

>d6cadb1 d.144.1.7 (B:449-705) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylh
aksiihrdlksnniflhedntvkigdfglatvksrwsgshqfeqlsgsilwmapevirmq
dsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkr
mkrlmaeclkkkrderp

Sequence, based on observed residues (ATOM records):

>d6cadb1 d.144.1.7 (B:449-705) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dweipdgqitvgqrigsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrh
vnillfmgystkpqlaivtqwcegsslyhhlhastkfemkklidiarqtargmdylhaks
iihrdlksnniflhedntvkigdfsgsilwmapevirmpysfqsdvyafgivlyelmtgq
lpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderp

Timeline for d6cadb1:

• d6cadb1 first appeared in SCOPe 2.07