SCOPe 2.08: Domain d6cnxd_: 6cnx D:

Lineage for d6cnxd_ (6cnx D:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d6cnxd_: 6cnx D: [350321]
   automated match to d6bu6a_
   complexed with act, f87, fcs, gol, so4

Details for d6cnxd_

PDB Entry: 6cnx, 2 Å

PDB Description: crystal structure of the human vaccinia-related kinase 1 (vrk1) bound to an n-propynyl-n-isopentyl-dihydropteridin inhibitor

PDB Compounds: (D:) Serine/threonine-protein kinase VRK1

SCOPe Domain Sequences for d6cnxd_:

Sequence, based on SEQRES records:

>d6cnxd_ d.144.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
avgeiitdmaaaawkvglpigqggfgciyladmnssesvgsdapcvvkvepsdngplfte
lkfyqraakpeqiqkwirtrklkylgvpkywgsglhdkngksyrfmimdrfgsdlqkiye
anakrfsrktvlqlslrildileyiheheyvhgdikasnlllnyknpdqvylvdyglayr
ycpegvhkayaadpkrchdgtieftsidahngvapsrrgdleilgycmiqwltghlpwed
nlkdpkyvrdskiryreniaslmdkcfpaanapgeiakymetvklldytekplyenlrdi
llqglkaigskddgkldl

Sequence, based on observed residues (ATOM records):

>d6cnxd_ d.144.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
avgeiitdmaaaawkvglpiciyladmnssesvgsdapcvvkvepsdngplftelkfyqr
aakpeqiqkwirtrklkylgvpkywgsglhdkngksyrfmimdrfgsdlqkiyeanakrf
srktvlqlslrildileyiheheyvhgdikasnlllnyknpdqvylvdyglayrycpegv
hkayaadpkrchdgtieftsidahngvapsrrgdleilgycmiqwltghlpwednlkdpk
yvrdskiryreniaslmdkcfpaanapgeiakymetvklldytekplyenlrdillqglk
aigskddgkldl

Timeline for d6cnxd_:

• d6cnxd_ first appeared in SCOPe 2.07