SCOPe 2.08: Domain d6bz2b_: 6bz2 B:

Lineage for d6bz2b_ (6bz2 B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (9 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (590 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d6bz2b_: 6bz2 B: [349884]
   automated match to d1sdta_
   complexed with 7oa, act, cl, na

Details for d6bz2b_

PDB Entry: 6bz2, 1.67 Å

PDB Description: crystal structure of wild-type hiv-1 protease with a novel hiv-1 inhibitor grl-14213a of 6-5-5-ring fused crown-like tetrahydropyranofuran as the p2-ligand, a cyclopropylaminobenzothiazole as the p2'-ligand and 3,5- difluorophenylmethyl as the p1-ligand

PDB Compounds: (B:) Protease

SCOPe Domain Sequences for d6bz2b_:

Sequence; same for both SEQRES and ATOM records:

>d6bz2b_ b.50.1.1 (B:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
qiiieiaghkaigtvlvgptpvniigrnlltqigatlnf

Timeline for d6bz2b_:

• d6bz2b_ first appeared in SCOPe 2.07