SCOPe 2.08: Domain d5x2aa_: 5x2a A:

Lineage for d5x2aa_ (5x2a A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d5x2aa_: 5x2a A: [348549]
   automated match to d4zseb_
   complexed with 7xo, anp, cl, edo, mg

Details for d5x2aa_

PDB Entry: 5x2a, 1.85 Å

PDB Description: crystal structure of egfr 696-1022 t790m/v948r in complex with sklb(3)

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5x2aa_:

Sequence, based on SEQRES records:

>d5x2aa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpik
wmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppic
tidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyr
almdeedmddvv

Sequence, based on observed residues (ATOM records):

>d5x2aa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllvpikwmalesilhriyt
hqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwm
idadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmvv

Timeline for d5x2aa_:

• d5x2aa_ first appeared in SCOPe 2.07