SCOPe 2.08: Domain d5w3ia1: 5w3i A:1-196

Lineage for d5w3ia1 (5w3i A:1-196)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.52: Restriction endonuclease-like [52979] (4 superfamilies)
   core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest

4. Superfamily c.52.1: Restriction endonuclease-like [52980] (37 families)

5. Family c.52.1.34: PA N-terminal domain [254166] (3 proteins)
   Pfam PF00603; relationship to endonucleases discussed in PubMed 19194458

6. Protein PA N-terminal domain [254375] (8 species)

7. Species Influenza A virus [TaxId:93838] [254808] (91 PDB entries)

8. Domain d5w3ia1: 5w3i A:1-196 [348017]
   Other proteins in same PDB: d5w3ia2
   automated match to d4e5ed_
   complexed with gol, gy5, mn

Details for d5w3ia1

PDB Entry: 5w3i, 1.95 Å

PDB Description: crystal structure of the influenza virus pa endonuclease in complex with inhibitor 6e (sri-29685)

PDB Compounds: (A:) Polymerase acidic protein

SCOPe Domain Sequences for d5w3ia1:

Sequence, based on SEQRES records:

>d5w3ia1 c.52.1.34 (A:1-196) PA N-terminal domain {Influenza A virus [TaxId: 93838]}
medfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdggskhrfeii
egrdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyylekankik
sekthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqser

Sequence, based on observed residues (ATOM records):

>d5w3ia1 c.52.1.34 (A:1-196) PA N-terminal domain {Influenza A virus [TaxId: 93838]}
medfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdggskhrfeii
egrdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyylekankie
kthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqser

Timeline for d5w3ia1:

• d5w3ia1 first appeared in SCOPe 2.07