SCOPe 2.08: Domain d5uz0b2: 5uz0 B:201-592

Lineage for d5uz0b2 (5uz0 B:201-592)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.97: Cytidine deaminase-like [53926] (2 superfamilies)
   core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta-sheet of 4 strands, order 2134; strand 1 is antiparallel to the rest

4. Superfamily c.97.1: Cytidine deaminase-like [53927] (7 families)
   contains extra C-terminal strand 5, order 21345

5. Family c.97.1.4: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC [64198] (2 proteins)
   duplication: consists of two domains of this fold with extra secondary structures within and in between the two core motifs

6. Protein automated matches [347771] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [347772] (2 PDB entries)

8. Domain d5uz0b2: 5uz0 B:201-592 [347876]
   Other proteins in same PDB: d5uz0a1, d5uz0b1, d5uz0c1, d5uz0d1
   automated match to d1pkxa2
   complexed with 8us, amz, mg

Details for d5uz0b2

PDB Entry: 5uz0, 1.79 Å

PDB Description: crystal structure of aicarft bound to an antifolate

PDB Compounds: (B:) Bifunctional purine biosynthesis protein PURH

SCOPe Domain Sequences for d5uz0b2:

Sequence; same for both SEQRES and ATOM records:

>d5uz0b2 c.97.1.4 (B:201-592) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vsqmplrygmnphqtpaqlytlqpklpitvlngapgfinlcdalnawqlvkelkealgip
aaasfkhvspagaavgiplsedeakvcmvydlyktltpisaayarargadrmssfgdfva
lsdvcdvptakiisrevsdgiiapgyeeealtilskkkngnycvlqmdqsykpdenevrt
lfglhlsqkrnngvvdkslfsnvvtknkdlpesalrdlivatiavkytqsnsvcyakngq
vigigagqqsrihctrlagdkanywwlrhhpqvlsmkfktgvkraeisnaidqyvtgtig
ededlikwkalfeevpellteaekkewvekltevsissdaffpfrdnvdrakrsgvayia
apsgsaadkvvieacdelgiilahtnlrlfhh

Timeline for d5uz0b2:

• d5uz0b2 first appeared in SCOPe 2.07