SCOPe 2.08: Domain d5ujib_: 5uji B:

Lineage for d5ujib_ (5uji B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
   core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.26.1: Nucleotidylyl transferase [52374] (6 families)

5. Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain [52375] (13 proteins)
   contains a conserved all-alpha subdomain at the C-terminal extension

6. Protein Tryptophanyl-tRNA synthetase (TrpRS) [52378] (5 species)
   overall structure is similar to TyrRS

7. Species Human (Homo sapiens) [TaxId:9606] [102256] (13 PDB entries)
   Uniprot P23381 94-471

8. Domain d5ujib_: 5uji B: [347641]
   automated match to d2qujb_
   mutant

Details for d5ujib_

PDB Entry: 5uji, 2.79 Å

PDB Description: crystal structure of human t2-tryptophanyl-trna synthetase with h130r mutation

PDB Compounds: (B:) Tryptophan--tRNA ligase, cytoplasmic

SCOPe Domain Sequences for d5ujib_:

Sequence, based on SEQRES records:

>d5ujib_ c.26.1.1 (B:) Tryptophanyl-tRNA synthetase (TrpRS) {Human (Homo sapiens) [TaxId: 9606]}
gidydklivrfgsskidkelinrieratgqrphrflrrgiffshrdmnqvldayenkkpf
ylytgrgpsseamhvghlipfiftkwlqdvfnvplviqmtddekylwkdltldqaysyav
enakdiiacgfdinktfifsdldymgmssgfyknvvkiqkhvtfnqvkgifgftdsdcig
kisfpaiqaapsfsnsfpqifrdrtdiqclipcaidqdpyfrmtrdvaprigypkpallh
stffpalqgaqtkmsasdpnssifltdtakqiktkvnkhafsggrdtieehrqfggncdv
dvsfmyltffledddkleqirkdytsgamltgelkkalievlqpliaehqarrkevtdei
vkefmtprklsfdf

Sequence, based on observed residues (ATOM records):

>d5ujib_ c.26.1.1 (B:) Tryptophanyl-tRNA synthetase (TrpRS) {Human (Homo sapiens) [TaxId: 9606]}
gidydklivrfgsskidkelinrieratgqrphrflrrgiffshrdmnqvldayenkkpf
ylytgrgpssamhvghlipfiftkwlqdvfnvplviqmtddekylwkdltldqaysyave
nakdiiacgfdinktfifsdldymgmssgfyknvvkiqkhvtfnqvkgifgftdsdcigk
isfpaiqaapsfsnsfpqifrdrtiqclipcaidqdpyfrmtrdvaprigypkpallhst
ffpalqgaqtkdpnssifltdtakqiktkvnkhafsgncdvdvsfmyltffledddkleq
irkdytgamltgelkkalievlqpliaehqarrkevtdeivkefmtprklsfdf

Timeline for d5ujib_:

• d5ujib_ first appeared in SCOPe 2.07