SCOPe 2.06: Domain d1f8ua_: 1f8u A:

Lineage for d1f8ua_ (1f8u A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
   automatically mapped to Pfam PF00135

6. Protein Acetylcholinesterase [53476] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53480] (11 PDB entries)

8. Domain d1f8ua_: 1f8u A: [34620]
   Other proteins in same PDB: d1f8ub_
   mutant

Details for d1f8ua_

PDB Entry: 1f8u, 2.9 Å

PDB Description: crystal structure of mutant e202q of human acetylcholinesterase complexed with green mamba venom peptide fasciculin-ii

PDB Compounds: (A:) acetylcholinesterase

SCOPe Domain Sequences for d1f8ua_:

Sequence, based on SEQRES records:

>d1f8ua_ c.69.1.1 (A:) Acetylcholinesterase {Human (Homo sapiens) [TaxId: 9606]}
daellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdatt
fqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggfy
sgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwvq
envaafggdptsvtlfgqsagaasvgmhllsppsrglfhravlqsgapngpwatvgmgea
rrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvd
gdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvr
vgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgar
vyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfa
rtgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat

Sequence, based on observed residues (ATOM records):

>d1f8ua_ c.69.1.1 (A:) Acetylcholinesterase {Human (Homo sapiens) [TaxId: 9606]}
daellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdatt
fqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggfy
sgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwvq
envaafggdptsvtlfgqsagaasvgmhllsppsrglfhravlqsgapngpwatvgmgea
rrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdflsd
tpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpqv
sdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayvf
ehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdpn
eppkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat

Timeline for d1f8ua_:

• d1f8ua_ first appeared (with stable ids) in SCOP 1.55
  
• d1f8ua_ appears in SCOPe 2.05
  
• d1f8ua_ appears in SCOPe 2.07
  
• d1f8ua_ appears in the current release, SCOPe 2.08