Lineage for d1evea_ (1eve A:)

  1. Root: SCOPe 2.02
  2. 1143363Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1178944Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
  4. 1178945Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families) (S)
    many members have left-handed crossover connection between strand 8 and additional strand 9
  5. 1178946Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
  6. 1178947Protein Acetylcholinesterase [53476] (5 species)
  7. 1179006Species Pacific electric ray (Torpedo californica) [TaxId:7787] [53477] (76 PDB entries)
    Uniprot P04058 25-556
  8. 1179054Domain d1evea_: 1eve A: [34585]
    complexed with e20, nag

Details for d1evea_

PDB Entry: 1eve (more details), 2.5 Å

PDB Description: three dimensional structure of the anti-alzheimer drug, e2020 (aricept), complexed with its target acetylcholinesterase
PDB Compounds: (A:) acetylcholinesterase

SCOPe Domain Sequences for d1evea_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1evea_ c.69.1.1 (A:) Acetylcholinesterase {Pacific electric ray (Torpedo californica) [TaxId: 7787]}
dhsellvntksgkvmgtrvpvlsshisaflgipfaeppvgnmrfrrpepkkpwsgvwnas
typnncqqyvdeqfpgfsgsemwnpnremsedclylniwvpsprpksttvmvwiygggfy
sgsstldvyngkylayteevvlvslsyrvgafgflalhgsqeapgnvglldqrmalqwvh
dniqffggdpktvtifgesaggasvgmhilspgsrdlfrrailqsgspncpwasvsvaeg
rrravelgrnlncnlnsdeelihclrekkpqelidvewnvlpfdsifrfsfvpvidgeff
ptslesmlnsgnfkktqillgvnkdegsffllygapgfskdseskisredfmsgvklsvp
handlgldavtlqytdwmddnngiknrdglddivgdhnvicplmhfvnkytkfgngtyly
ffnhrasnlvwpewmgvihgyeiefvfglplvkelnytaeeealsrrimhywatfaktgn
pnephsqeskwplfttkeqkfidlntepmkvhqrlrvqmcvfwnqflpkllnat

SCOPe Domain Coordinates for d1evea_:

Click to download the PDB-style file with coordinates for d1evea_.
(The format of our PDB-style files is described here.)

Timeline for d1evea_: