SCOPe 2.07: Domain d4i43b4: 4i43 B:885-1652

Lineage for d4i43b4 (4i43 B:885-1652)

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.8: Splicing factor Prp8 RT domain [345981] (2 protein domains)
   Pfam PF10598, Pfam PF10597. Includes linker domain discussed in PubMed 23354046
   Homology to retroviral RT domains discussed in PubMed 21441348

6. Protein Pre-mRNA splicing factor 8, Prp8 / Spp42 [346115] (2 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [346406] (1 PDB entry)

8. Domain d4i43b4: 4i43 B:885-1652 [345297]
   Other proteins in same PDB: d4i43a1, d4i43a2, d4i43b1, d4i43b2, d4i43b3, d4i43b5
   protein/RNA complex

Details for d4i43b4

PDB Entry: 4i43, 2 Å

PDB Description: crystal structure of prp8:aar2 complex

PDB Compounds: (B:) Pre-mRNA-splicing factor 8

SCOPe Domain Sequences for d4i43b4:

Sequence, based on SEQRES records:

>d4i43b4 e.8.1.8 (B:885-1652) Pre-mRNA splicing factor 8, Prp8 / Spp42 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 559292]}
vmvewlesrsfspipfppltykndtkilvlaledlkdvyaskvrlnasereelalieeay
dnphdtlnrikkylltqrvfkpvditmmenyqnispvysvdplekitdayldqylwyead
qrklfpnwikpsdseippllvykwtqginnlseiwdvsrgqsavllettlgemaekidft
llnrllrlivdpniadyitaknnvvinfkdmshvnkyglirglkfasfifqyyglvidll
llgqeratdlagpannpnefmqfkskevekahpirlytryldriymlfhfeedegeeltd
eylaenpdpnfensigynnrkcwpkdsrmrlirqdvnlgravfweiqsrvptsltsikwe
nafvsvysknnpnllfsmcgfevrilprqrmeevvsndegvwdlvdertkqrtakaylkv
seeeikkfdsrirgilmasgsttftkvaakwntslislftyfreaivateplldilvkge
triqnrvklglnskmptrfppavfytpkelgglgmisashilipasdlswskqtdtgith
fragmthedekliptifryittwenefldsqrvwaeyatkrqeaiqqnrrlafeelegsw
drgipristlfqrdrhtlaydrghrirrefkqyslernspfwwtnshhdgklwnlnayrt
dviqalggietilehtlfkgtgfnsweglfwekasgfedsmqfkklthaqrtglsqipnr
rftlwwsptinranvyvgflvqldltgiflhgkiptlkisliqifrah

Sequence, based on observed residues (ATOM records):

>d4i43b4 e.8.1.8 (B:885-1652) Pre-mRNA splicing factor 8, Prp8 / Spp42 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 559292]}
vmvewlesrsfspipfppltykndtkilvlaledlkdvyaskvrlnasereelalieeay
dnphdtlnrikkylltqrvfkpvditpvysvdplekitdayldqylwyeadqrklfpnwi
kpsdseippllvykwtqginnlseiwdvsrgqsavllettlgemaekidftllnrllrli
vdpniadyitaknnvvinfkdmshvnkyglirglkfasfifqyyglvidllllgqeratd
lagpannpnefmqfkskevekahpirlytryldriymlfhfeedegeeltdeylaenpdp
nfensigynnrkcwpkdsrmrlirqdvnlgravfweiqsrvptsltsikwenafvsvysk
nnpnllfsmcgfevrilprqrmeendegvwdlvdertkqrtakaylkvseeeikkfdsri
rgilmasttftkvaakwntslislftyfreaivateplldilvkgetriqnrvklglnsk
mptrfppavfytpkelgglgmisashilipasdlswskqtdtgithfragmthedeklip
tifryittwenefldsqrvwaeyatkrqeaiqqnrrlafeelegswdrgipristlfqrd
rhtlaydrghrirrefkqyslernspfwwtnshhdgklwnlnayrtdviqalggietile
htlfkgtgfnsweglfwlsqipnrrftlwwsptinranvyvgflvqldltgiflhgkipt
lkisliqifrah

Timeline for d4i43b4:

• d4i43b4 is new in SCOPe 2.07-stable