SCOPe 2.08: Domain d2wx2b1: 2wx2 B:28-481

Lineage for d2wx2b1 (2wx2 B:28-481)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (99 species)
   not a true protein

7. Species Trypanosoma cruzi [TaxId:5693] [196511] (20 PDB entries)

8. Domain d2wx2b1: 2wx2 B:28-481 [344672]
   Other proteins in same PDB: d2wx2b2
   automated match to d4uhia_
   complexed with hem, tpf

Details for d2wx2b1

PDB Entry: 2wx2, 2.27 Å

PDB Description: x-ray structure of cyp51 from the human pathogen trypanosoma cruzi in complex with fluconazole

PDB Compounds: (B:) lanosterol 14-alpha-demethylase

SCOPe Domain Sequences for d2wx2b1:

Sequence, based on SEQRES records:

>d2wx2b1 a.104.1.0 (B:28-481) automated matches {Trypanosoma cruzi [TaxId: 5693]}
rptdppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehs
rffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiq
hevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmess
lipaavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllk
avyrdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefp
aqlnydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacsplls
hhdeeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfql
lrdevpdpdyhtmvvgptlnqclvkytrkkklps

Sequence, based on observed residues (ATOM records):

>d2wx2b1 a.104.1.0 (B:28-481) automated matches {Trypanosoma cruzi [TaxId: 5693]}
rptdppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehs
rffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiq
hevrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllslipaa
vfmpwllrlplpqsarcrearaelqkilgeiivareksdllggllkavyrdgtrmslhev
cgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnvmdempf
aercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafpnprlwd
perdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdpdyhtmv
vgptlnqclvkytrkkklps

Timeline for d2wx2b1:

• d2wx2b1 first appeared in SCOPe 2.07