SCOPe 2.08: Domain d2wv2a_: 2wv2 A:

Lineage for d2wv2a_ (2wv2 A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (99 species)
   not a true protein

7. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [194968] (9 PDB entries)

8. Domain d2wv2a_: 2wv2 A: [344670]
   automated match to d4uhia_
   complexed with hem, tpf

Details for d2wv2a_

PDB Entry: 2wv2, 2.7 Å

PDB Description: X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole

PDB Compounds: (A:) lanosterol 14-alpha-demethylase

SCOPe Domain Sequences for d2wv2a_:

Sequence, based on SEQRES records:

>d2wv2a_ a.104.1.0 (A:) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
tdppvypvtvpilghiiqfgksplgfmqeckrqlksgiftinivgkrvtivgdphehsrf
flprnevlsprevysfmvpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhe
vrkfmaanwdkdegeinlledcstmiintacqclfgedlrkrldarrfaqllakmessli
paavflpillklplpqsarcheartelqkilseiiiarkeeevnkdsstsdllsgllsav
yrdgtpmslhevcgmivaamfagqhtssitttwsmlhlmhpanvkhlealrkeieefpaq
lnynnvmdempfaercaresirrdppllmlmrkvmadvkvgsyvvpkgdiiacspllshh
deeafpeprrwdperdekvegafigfgagvhkcigqkfgllqvktilatafrsydfqllr
devpdpdyhtmvvgptasqcrvkyirrk

Sequence, based on observed residues (ATOM records):

>d2wv2a_ a.104.1.0 (A:) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
tdppvypvtvpilghiiqfgksplgfmqeckrqlksgiftinivgkrvtivgdphehsrf
flprnevlsprevysfmvpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhe
vrkfmaanwdkdegeinlledcstmiintacqclfgedlrkrldarrfaqllakmessli
paavflpillklplpqsarcheartelqkilseiiiarkeeevtsdllsgllsavyrdgt
pmslhevcgmivaamfagqhtssitttwsmlhlmhpanvkhlealrkeieefpaqlnynn
vmdempfaercaresirrdppllmlmrkvmadvkvgsyvvpkgdiiacspllshhdeeaf
peprrwdperdekvegafigfgagvhkcigqkfgllqvktilatafrsydfqllrdevpd
pdyhtmvvgptasqcrvkyirrk

Timeline for d2wv2a_:

• d2wv2a_ first appeared in SCOPe 2.07