Lineage for d5xzra1 (5xzr A:1-110)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2530460Fold d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices
  4. 2530461Superfamily d.93.1: SH2 domain [55550] (2 families) (S)
  5. 2530930Family d.93.1.0: automated matches [191409] (1 protein)
    not a true family
  6. 2530931Protein automated matches [190561] (4 species)
    not a true protein
  7. 2530932Species Human (Homo sapiens) [TaxId:9606] [187549] (57 PDB entries)
  8. 2531009Domain d5xzra1: 5xzr A:1-110 [342909]
    Other proteins in same PDB: d5xzra3
    automated match to d2b3oa1
    complexed with 8j6; mutant

Details for d5xzra1

PDB Entry: 5xzr (more details), 2.8 Å

PDB Description: the atomic structure of shp2 e76a mutant in complex with allosteric inhibitor 9b
PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d5xzra1:

Sequence; same for both SEQRES and ATOM records: (download)

>d5xzra1 d.93.1.0 (A:1-110) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
dyydlyggekfatlaalvqyymehhgqlkekngdvielkyplncadptse

SCOPe Domain Coordinates for d5xzra1:

Click to download the PDB-style file with coordinates for d5xzra1.
(The format of our PDB-style files is described here.)

Timeline for d5xzra1: