SCOPe 2.06: Domain d5wn8a_: 5wn8 A:

Lineage for d5wn8a_ (5wn8 A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
   multihelical; bundle, contains interrupted helices

4. Superfamily a.266.1: Indolic compounds 2,3-dioxygenase-like [140959] (3 families)
   contains heme-dependent enzymes

5. Family a.266.1.2: Indoleamine 2,3-dioxygenase-like [140963] (3 proteins)
   Pfam PF01231; contains extra N-terminal all-alpha subdomain of similar fold to the GST C-terminal domain (47615)

6. Protein automated matches [190585] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187592] (13 PDB entries)

8. Domain d5wn8a_: 5wn8 A: [342545]
   automated match to d4u72b_
   complexed with bbj, hem

Details for d5wn8a_

PDB Entry: 5wn8, 2.5 Å

PDB Description: structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

PDB Compounds: (A:) Indoleamine 2,3-dioxygenase 1

SCOPe Domain Sequences for d5wn8a_:

Sequence, based on SEQRES records:

>d5wn8a_ a.266.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdh
ksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvlan
wkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqer
dtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfw
edpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsedpsk
leakgtggtdlmnflktvrstteksllke

Sequence, based on observed residues (ATOM records):

>d5wn8a_ a.266.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdh
ksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvlan
wkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqer
dtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfw
edpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesn
psvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqtggtdlmnflktv
rstteksllke

Timeline for d5wn8a_:

• d5wn8a_ is new in SCOPe 2.06-stable
  
• d5wn8a_ appears in SCOPe 2.07
  
• d5wn8a_ appears in the current release, SCOPe 2.08