SCOPe 2.06: Domain d5toba_: 5tob A:

Lineage for d5toba_ (5tob A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (17 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)

8. Domain d5toba_: 5tob A: [342186]
   automated match to d3cc6a_
   complexed with yam

Details for d5toba_

PDB Entry: 5tob, 2.12 Å

PDB Description: selectivity switch between fak and pyk2: macrocyclization of fak inhibitors improves pyk2 potency

PDB Compounds: (A:) Protein-tyrosine kinase 2-beta

SCOPe Domain Sequences for d5toba_:

Sequence, based on SEQRES records:

>d5toba_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iaredvvlnrilgegffgevyegvytnhkgekinvavktckkdctldnkekfmseavimk
nldhphivkligiieeeptwiimelypygelghylernknslkvltlvlyslqickamay
lesincvhrdiavrnilvaspecvklgdfglsryiededyykasvtrlpikwmspesinf
rrfttasdvwmfavcmweilsfgkqpffwlenkdvigvlekgdrlpkpdlcppvlytlmt
rcwdydpsdrprftelvcslsdvyqmekdia

Sequence, based on observed residues (ATOM records):

>d5toba_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iaredvvlnrilgegffgevyegvythkgekinvavktckdnkekfmseavimknldhph
ivkligiieptwiimelypygelghylernknslkvltlvlyslqickamaylesincvh
rdiavrnilvaspecvklgdfgpikwmspesinfrrfttasdvwmfavcmweilsfgkqp
ffwlenkdvigvlekgdrlpkpdlcppvlytlmtrcwdydpsdrprftelvcslsdvyqm
ekdia

Timeline for d5toba_:

• d5toba_ is new in SCOPe 2.06-stable
  
• d5toba_ appears in SCOPe 2.07
  
• d5toba_ appears in the current release, SCOPe 2.08