Lineage for d5tmgb_ (5tmg B:)

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2799129Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2799130Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2800798Family b.50.1.2: Pepsin-like [50646] (11 proteins)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2801389Protein Chymosin (synonym: renin) [50667] (3 species)
  7. 2801397Species Human (Homo sapiens) [TaxId:9606] [50669] (77 PDB entries)
  8. 2801429Domain d5tmgb_: 5tmg B: [340306]
    automated match to d1hrna_
    complexed with 7ek, dms, nag, peg, pge

Details for d5tmgb_

PDB Entry: 5tmg (more details), 2.2 Å

PDB Description: optimization of 3,5-disubstitued piperidine: discovery of non-peptide mimetics as an orally active renin inhibitor
PDB Compounds: (B:) renin

SCOPe Domain Sequences for d5tmgb_:

Sequence, based on SEQRES records: (download)

>d5tmgb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records): (download)

>d5tmgb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsqslggqivlggsdpqhy
egnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmeal
gakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdip
pptgptwalgatfirkfytefdrrnnrigfalar

SCOPe Domain Coordinates for d5tmgb_:

Click to download the PDB-style file with coordinates for d5tmgb_.
(The format of our PDB-style files is described here.)

Timeline for d5tmgb_: