SCOPe 2.06: Domain d5w9da_: 5w9d A:

Lineage for d5w9da_ (5w9d A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (64 PDB entries)
   Uniprot P03372 307-551

8. Domain d5w9da_: 5w9d A: [340173]
   automated match to d3erta_
   complexed with 9xy; mutant

Details for d5w9da_

PDB Entry: 5w9d, 1.65 Å

PDB Description: estrogen receptor alpha ligand binding domain c381s, c417s, c530s mutant in complex with endoxifen

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d5w9da_:

Sequence, based on SEQRES records:

>d5w9da_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda
hrlh

Sequence, based on observed residues (ATOM records):

>d5w9da_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpeasmmglltnladrelvhminwakrvpgfv
dltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdml
latssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlih
lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemldahr
lh

Timeline for d5w9da_:

• d5w9da_ is new in SCOPe 2.06-stable
  
• d5w9da_ appears in SCOPe 2.07
  
• d5w9da_ appears in the current release, SCOPe 2.08