SCOPe 2.06: Domain d5v7ib_: 5v7i B:

Lineage for d5v7ib_ (5v7i B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.67: PLP-dependent transferase-like [53382] (3 superfamilies)
   main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest

4. Superfamily c.67.1: PLP-dependent transferases [53383] (10 families)

5. Family c.67.1.4: GABA-aminotransferase-like [53417] (17 proteins)
   formerly omega-Aminoacid:pyruvate aminotransferase-like

6. Protein Serine hydroxymethyltransferase [53429] (6 species)

7. Species Human (Homo sapiens), mitochondrial [TaxId:9606] [142671] (4 PDB entries)
   Uniprot P34897 42-504

8. Domain d5v7ib_: 5v7i B: [340115]
   automated match to d3ou5a_
   complexed with 8z1, gly, gol, peg

Details for d5v7ib_

PDB Entry: 5v7i, 2.47 Å

PDB Description: crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (shmt2), in complex with glycine, plp and folate- competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4- (3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile

PDB Compounds: (B:) Serine hydroxymethyltransferase, mitochondrial

SCOPe Domain Sequences for d5v7ib_:

Sequence; same for both SEQRES and ATOM records:

>d5v7ib_ c.67.1.4 (B:) Serine hydroxymethyltransferase {Human (Homo sapiens), mitochondrial [TaxId: 9606]}
wtgqeslsdsdpemwellqrekdrqcrgleliasenfcsraalealgsclnnkysegypg
kryyggaevvdeiellcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrim
gldlpdgghlthgymsdvkrisatsiffesmpyklnpktglidynqlaltarlfrprlii
agtsayarlidyarmrevcdevkahlladmahisglvaakvipspfkhadivtttthktl
rgarsglifyrkgvkavdpktgreipytfedrinfavfpslqggphnhaiaavavalkqa
ctpmfreyslqvlknaramadallergyslvsggtdnhlvlvdlrpkgldgaraervlel
vsitankntcpgdrsaitpgglrlgapaltsrqfreddfrrvvdfidegvniglevkskt
aklqdfksfllkdsetsqrlanlrqrveqfarafpmpgfdeh

Timeline for d5v7ib_:

• d5v7ib_ is new in SCOPe 2.06-stable
  
• d5v7ib_ appears in SCOPe 2.07
  
• d5v7ib_ appears in the current release, SCOPe 2.08