SCOPe 2.06: Domain d5y5na_: 5y5n A:

Lineage for d5y5na_ (5y5n A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein Sirt2 histone deacetylase [63987] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63988] (3 PDB entries)

8. Domain d5y5na_: 5y5n A: [338859]
   automated match to d1j8fa_
   complexed with 8no, zn

Details for d5y5na_

PDB Entry: 5y5n, 2.3 Å

PDB Description: crystal structure of human sirtuin 2 in complex with a selective inhibitor

PDB Compounds: (A:) nad-dependent protein deacetylase sirtuin-2

SCOPe Domain Sequences for d5y5na_:

Sequence, based on SEQRES records:

>d5y5na_ c.31.1.5 (A:) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
geadmdflrnlfsqtlslgsqkerlldeltlegvarymqsercrrviclvgagistsagi
pdfrspstglydnlekyhlpypeaifeisyfkkhpepffalakelypgqfkptichyfmr
llkdkglllrcytqnidtleriagleqedlveahgtfytshcvsascrheyplswmkeki
fsevtpkcedcqslvkpdivffgeslparffscmqsdflkvdlllvmgtslqvqpfasli
skaplstprllinkekagqsdpflgmimglgggmdlgetpfddiatfdskkayrdvawlg
ecdqgclalaellgwkkeledlvrrehasidaqs

Sequence, based on observed residues (ATOM records):

>d5y5na_ c.31.1.5 (A:) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
geadmdflrnlfsqtlslgsqkerlldeltlegvarymqsercrrviclvgagistsagi
pdfrsphlpypeaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrc
ytqnidtleriagleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedc
qslvkpdivffgeslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprll
inkekayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

Timeline for d5y5na_:

• d5y5na_ is new in SCOPe 2.06-stable
  
• d5y5na_ appears in SCOPe 2.07
  
• d5y5na_ appears in the current release, SCOPe 2.08