Lineage for d5oq4a4 (5oq4 A:726-1091)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218054Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)
  6. 2218055Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)
  7. 2218056Species Human (Homo sapiens) [TaxId:9606] [56174] (65 PDB entries)
  8. 2218114Domain d5oq4a4: 5oq4 A:726-1091 [338602]
    Other proteins in same PDB: d5oq4a1, d5oq4a2, d5oq4a3
    automated match to d1e8za4
    complexed with a3w, so4

Details for d5oq4a4

PDB Entry: 5oq4 (more details), 2.7 Å

PDB Description: pqr309 - a potent, brain-penetrant, orally bioavailable, pan-class i pi3k/mtor inhibitor as clinical candidate in oncology
PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d5oq4a4:

Sequence, based on SEQRES records: (download)

>d5oq4a4 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlv

Sequence, based on observed residues (ATOM records): (download)

>d5oq4a4 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnslpesfrvp
ydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilq
ilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgfkdevl
nhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgh
ilgervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmt
gmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlv

SCOPe Domain Coordinates for d5oq4a4:

Click to download the PDB-style file with coordinates for d5oq4a4.
(The format of our PDB-style files is described here.)

Timeline for d5oq4a4: