SCOPe 2.08: Domain d5oq4a1: 5oq4 A:145-321

Lineage for d5oq4a1 (5oq4 A:145-321)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (15 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)

8. Domain d5oq4a1: 5oq4 A:145-321 [338599]
   Other proteins in same PDB: d5oq4a2, d5oq4a3, d5oq4a4
   automated match to d1e8za3
   complexed with a3w, so4
   has additional insertions and/or extensions that are not grouped together

Details for d5oq4a1

PDB Entry: 5oq4, 2.7 Å

PDB Description: pqr309 - a potent, brain-penetrant, orally bioavailable, pan-class i pi3k/mtor inhibitor as clinical candidate in oncology

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d5oq4a1:

Sequence, based on SEQRES records:

>d5oq4a1 d.15.1.5 (A:145-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipes
qseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d5oq4a1 d.15.1.5 (A:145-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkqdfvlrvcgrdey
lvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d5oq4a1:

• d5oq4a1 first appeared in SCOPe 2.06
  
• d5oq4a1 appears in SCOPe 2.07