SCOPe 2.07: Domain d5kyeb_: 5kye B:

Lineage for d5kyeb_ (5kye B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (6 proteins)
   Pfam PF00443

6. Protein Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) [82569] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82570] (24 PDB entries)

8. Domain d5kyeb_: 5kye B: [337663]
   Other proteins in same PDB: d5kyec_, d5kyed_
   automated match to d1nbfa_
   complexed with epe; mutant

Details for d5kyeb_

PDB Entry: 5kye, 1.97 Å

PDB Description: crystal structure of usp7 catalytic domain [h294e] mutant in complex with ubiquitin

PDB Compounds: (B:) Ubiquitin carboxyl-terminal hydrolase 7

SCOPe Domain Sequences for d5kyeb_:

Sequence, based on SEQRES records:

>d5kyeb_ d.3.1.9 (B:) Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) {Human (Homo sapiens) [TaxId: 9606]}
tgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyelqhs
dkpvgtkkltksfgwetldsfmqedvqelcrvlldnvenkmkgtcvegtipklfrgkmvs
yiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglqeae
kgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdpanyil
havlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddlsvrhc
tnaymlvyiresklsevlqavtdhdipqqlverlqeekr

Sequence, based on observed residues (ATOM records):

>d5kyeb_ d.3.1.9 (B:) Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) {Human (Homo sapiens) [TaxId: 9606]}
tgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyelqhs
dkpvgtkkltksfgwetldsfmqedvqelcrvlldnvenkmkgtcvegtipklfrgkmvs
yiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglqeae
kgvkfltlppvlhlqlmrfmydpdqnikindrfefpeqlpldeflqktdpkdpanyilha
vlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnyggrhctnaymlvyi
resklsevlqavtdhdipqqlverlqeekr

Timeline for d5kyeb_:

• d5kyeb_ first appeared in SCOPe 2.06