SCOPe 2.08: Domain d5i8aa1: 5i8a A:501-787

Lineage for d5i8aa1 (5i8a A:501-787)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5i8aa1: 5i8a A:501-787 [337491]
   Other proteins in same PDB: d5i8aa2
   automated match to d3hmoa_
   complexed with 69c, act, cl

Details for d5i8aa1

PDB Entry: 5i8a, 2.33 Å

PDB Description: trka with (6~{r})-3-methylsulfanyl-6-phenyl-1-(1~{h}-pyrazol-3-yl)-6, 7-dihydro-5~{h}-thieno[3,4-c]pyridin-4-one

PDB Compounds: (A:) high affinity nerve growth factor receptor

SCOPe Domain Sequences for d5i8aa1:

Sequence, based on SEQRES records:

>d5i8aa1 d.144.1.0 (A:501-787) automated matches {Human (Homo sapiens) [TaxId: 9606]}
cvhhikrrdivlkwelgegafgkvflaechnllpeqdkmlvavkalkeasesarqdfqre
aelltmlqhqhivrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapg
plglgqllavasqvaagmvylaglhfvhrdlatrnclvgqglvvkigdfgmsrdiystdy
yrvggrtmlpirwmppesilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidci
tqgrelerpracppevyaimrgcwqrepqqrhsikdvharlqalaqa

Sequence, based on observed residues (ATOM records):

>d5i8aa1 d.144.1.0 (A:501-787) automated matches {Human (Homo sapiens) [TaxId: 9606]}
cvhhikrrdivlkwelgegkvflaechnkmlvavkalkdfqreaelltmlqhqhivrffg
vctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapgplglgqllavasqvaag
mvylaglhfvhrdlatrnclvgqglvvkigdfgsrdiystdyyrvtmlpirwmppesily
rkfttesdvwsfgvvlweiftygkqpwyqlsnteaidcitqgrelerpracppevyaimr
gcwqrepqqrhsikdvharlqalaqa

Timeline for d5i8aa1:

• d5i8aa1 first appeared in SCOPe 2.06
  
• d5i8aa1 appears in SCOPe 2.07