SCOPe 2.08: Domain d5vsea_: 5vse A:

Lineage for d5vsea_ (5vse A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.85: beta-clip [51268] (7 superfamilies)
   double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll

4. Superfamily b.85.7: SET domain [82199] (4 families)
   duplication: the core is composed of two structural repeats similar to (circularly permuted) repeats of AFPIII
   also contains a substrate-binding alpha+beta subdomain inserted in the core
   Pfam PF00856

5. Family b.85.7.0: automated matches [227191] (1 protein)
   not a true family

6. Protein automated matches [226914] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225158] (28 PDB entries)

8. Domain d5vsea_: 5vse A: [336870]
   Other proteins in same PDB: d5vseb2
   automated match to d3k5ka_
   complexed with 9hg, sam, zn

Details for d5vsea_

PDB Entry: 5vse, 1.6 Å

PDB Description: structure of human g9a set-domain (ehmt2) in complex with inhibitor 17: n~2~-cyclopentyl-6,7-dimethoxy-n~2~-methyl-n~4~-(1- methylpiperidin-4-yl)quinazoline-2,4-diamine

PDB Compounds: (A:) Histone-lysine N-methyltransferase EHMT2

SCOPe Domain Sequences for d5vsea_:

Sequence, based on SEQRES records:

>d5vsea_ b.85.7.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ekiicrdvargyenvpipcvngvdgepcpedykyisencetstmnidrnithlqhctcvd
dcsssnclcgqlsircwydkdgrllqefnkiepplifecnqacscwrncknrvvqsgikv
rlqlyrtakmgwgvralqtipqgtficeyvgelisdaeadvreddsylfdldnkdgevyc
idaryygnisrfinhlcdpniipvrvfmlhqdlrfpriaffssrdirtgeelgfdygdrf
wdikskyftcqcgsekckhsaeaialeqsrla

Sequence, based on observed residues (ATOM records):

>d5vsea_ b.85.7.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ekiicrdvargyenvpipcvngvdgepcpedykyisencetstmnidrnithlqhctcvd
dcsssnclcgqlsircwydkdgrllqefnkiepplifecnqacscwrncknrvvqsgikv
rlqlyrtakmgwgvralqtipqgtficeyvgelisdaeadvreddsylfdldnevycida
ryygnisrfinhlcdpniipvrvfmlhqdlrfpriaffssrdirtgeelgfdygdrfwdi
kskyftcqcgsekckhsaeaialeqsrla

Timeline for d5vsea_:

• d5vsea_ first appeared in SCOPe 2.06
  
• d5vsea_ appears in SCOPe 2.07