SCOPe 2.06: Domain d5pamb_: 5pam B:

Lineage for d5pamb_ (5pam B:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (88 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d5pamb_: 5pam B: [335803]
   Other proteins in same PDB: d5pama_
   automated match to d1klih_
   complexed with 7z1, ca, cl, gol, so4

Details for d5pamb_

PDB Entry: 5pam, 1.6 Å

PDB Description: crystal structure of factor viia in complex with 2-[(1- aminoisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluorophenyl)-1-(2- phenylpyrrolidin-1-yl)ethanone

PDB Compounds: (B:) Coagulation factor VII heavy chain

SCOPe Domain Sequences for d5pamb_:

Sequence, based on SEQRES records:

>d5pamb_ b.47.1.2 (B:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Sequence, based on observed residues (ATOM records):

>d5pamb_ b.47.1.2 (B:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrspniteymfcagysdgs
kdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrsepr
pgvllrapfp

Timeline for d5pamb_:

• d5pamb_ is new in SCOPe 2.06-stable
  
• d5pamb_ appears in SCOPe 2.07
  
• d5pamb_ appears in the current release, SCOPe 2.08