SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5wuxe_ (5wux E:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2041369Fold b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  4. 2041370Superfamily b.22.1: TNF-like [49842] (2 families) (S)
  5. 2041371Family b.22.1.1: TNF-like [49843] (15 protein domains)
  6. 2041626Protein automated matches [190204] (3 species)
    not a true protein
  7. 2041627Species Human (Homo sapiens) [TaxId:9606] [186956] (11 PDB entries)
  8. 2291939Domain d5wuxe_: 5wux E: [335240]
    automated match to d1a8ma_

Details for d5wuxe_

PDB Entry: 5wux (more details), 2.9 Å

PDB Description: tnfalpha-certolizumab fab
PDB Compounds: (E:) tumor necrosis factor alpha

SCOPe Domain Sequences for d5wuxe_:

Sequence, based on SEQRES records: (download)

>d5wuxe_ b.22.1.1 (E:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqg
cpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlek
gdrlsaeinrpdyldfaesgqvyfgiial

Sequence, based on observed residues (ATOM records): (download)

>d5wuxe_ b.22.1.1 (E:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sdkpvahvvanpqaegqlqwanallangvelrdnqlvvpseglyliysqvlfkgqgcpst
hvllthtisriavsyqtkvnllsaikspcakpwyepiylggvfqlekgdrlsaeinrpdy
ldfaesgqvyfgiial

SCOPe Domain Coordinates for d5wuxe_:

Click to download the PDB-style file with coordinates for d5wuxe_.
(The format of our PDB-style files is described here.)

Timeline for d5wuxe_:

  • d5wuxe_ appears in periodic updates to SCOPe 2.06 starting on 2017-06-08