SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5uada_ (5uad A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195690Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2197126Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2197127Species Human (Homo sapiens) [TaxId:9606] [103301] (52 PDB entries)
  8. 2291746Domain d5uada_: 5uad A: [335047]
    automated match to d3vw8a_
    complexed with 84p, cl

Details for d5uada_

PDB Entry: 5uad (more details), 2.25 Å

PDB Description: met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody
PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d5uada_:

Sequence, based on SEQRES records: (download)

>d5uada_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
tdmspiltsgdsdisspllqntvhidlsalnpelvqavqhvvigpsslivhfnevigrgh
fgcvyhgtlldndgkkihcavkslnritdigevsqfltegiimkdfshpnvlsllgiclr
segsplvvlpymkhgdlrnfirnethnptvkdligfglqvakgmkylaskkfvhrdlaar
ncmldekftvkvadfglardmydkeyysvhnktgaklpvkwmaleslqtqkfttksdvws
fgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrp
sfselvsrisaifstfigehyvhvnatyvnvk

Sequence, based on observed residues (ATOM records): (download)

>d5uada_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
tdmspinpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlhcavkslnigevsqf
ltegiimkdfshpnvlsllgiclplvvlpymkhgdlrnfirnethnptvkdligfglqva
kgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysvhnktgaklpvkw
maleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycp
dplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk

SCOPe Domain Coordinates for d5uada_:

Click to download the PDB-style file with coordinates for d5uada_.
(The format of our PDB-style files is described here.)

Timeline for d5uada_:

  • d5uada_ appears in periodic updates to SCOPe 2.06 starting on 2017-06-01