Lineage for d5truc_ (5tru C:)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2344608Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2344609Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2344610Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)
  6. 2346864Protein Immunoreceptor CTLA-4 (CD152), N-terminal fragment [48939] (2 species)
  7. 2346865Species Human (Homo sapiens) [TaxId:9606] [48940] (5 PDB entries)
  8. 2346871Domain d5truc_: 5tru C: [334767]
    Other proteins in same PDB: d5trul1, d5trul2
    automated match to d2x44d_

Details for d5truc_

PDB Entry: 5tru (more details), 3 Å

PDB Description: structure of the first-in-class checkpoint inhibitor ipilimumab bound to human ctla-4
PDB Compounds: (C:) cytotoxic t-lymphocyte protein 4

SCOPe Domain Sequences for d5truc_:

Sequence, based on SEQRES records: (download)

>d5truc_ b.1.1.1 (C:) Immunoreceptor CTLA-4 (CD152), N-terminal fragment {Human (Homo sapiens) [TaxId: 9606]}
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
flddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvi

Sequence, based on observed residues (ATOM records): (download)

>d5truc_ b.1.1.1 (C:) Immunoreceptor CTLA-4 (CD152), N-terminal fragment {Human (Homo sapiens) [TaxId: 9606]}
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
fdsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvi

SCOPe Domain Coordinates for d5truc_:

Click to download the PDB-style file with coordinates for d5truc_.
(The format of our PDB-style files is described here.)

Timeline for d5truc_: