SCOPe 2.08: Domain d5pzpa_: 5pzp A:

Lineage for d5pzpa_ (5pzp A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus genotype 1b (isolate con1) [TaxId:333284] [188792] (8 PDB entries)

8. Domain d5pzpa_: 5pzp A: [334324]
   automated match to d3q0za_
   protein/RNA complex; complexed with 23e, 8xj, gol, so4

Details for d5pzpa_

PDB Entry: 5pzp, 2.95 Å

PDB Description: crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase in complex with 4-fluoro-2-(4-fluorophenyl)-n-methyl-5-(2- methyl-5-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1- benzofuran-3-carboxamide (bms-929075)

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d5pzpa_:

Sequence, based on SEQRES records:

>d5pzpa_ e.8.1.4 (A:) automated matches {Hepatitis C virus genotype 1b (isolate con1) [TaxId: 333284]}
smsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhir
svwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkaa
aacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpip
aasqldlsswfvagysggdiyhslsrarprwfm

Sequence, based on observed residues (ATOM records):

>d5pzpa_ e.8.1.4 (A:) automated matches {Hepatitis C virus genotype 1b (isolate con1) [TaxId: 333284]}
smsytwtgalitpcyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakll
sveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakne
vfcvqpkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrveflvnaw
kakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyiggpltn
skgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvvicesag
tqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvyyltrdp
ttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekaldcqiy
gacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrhrarsvr
arllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyhslsrar
prwfm

Timeline for d5pzpa_:

• d5pzpa_ first appeared in SCOPe 2.06
  
• d5pzpa_ appears in SCOPe 2.07