SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5uzha_ (5uzh A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2091795Protein automated matches [190085] (51 species)
    not a true protein
  7. 2289498Species Naegleria fowleri [TaxId:5763] [332799] (1 PDB entry)
  8. 2289499Domain d5uzha_: 5uzh A: [332800]
    automated match to d1t2aa_
    complexed with cl, gdp, mpd, nap

Details for d5uzha_

PDB Entry: 5uzh (more details), 2.25 Å

PDB Description: crystal structure of a gdp-mannose dehydratase from naegleria fowleri
PDB Compounds: (A:) NafoA.00085.b

SCOPe Domain Sequences for d5uzha_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5uzha_ c.2.1.2 (A:) automated matches {Naegleria fowleri [TaxId: 5763]}
skvalitgitgqdgsylaefllekgymvygiirrsssfntgrvehlykdihitkakfkll
ygdltdtgnlisiiakikpdeiynlaaqshvkvsfempeytanvdgigtlrlleairacg
lekktkfyqastselyglvqevpqkettpfyprspyacaklysywivvnyreaynmfaln
gilfnhesirrgptfvtrkitmavariklglqdclylgnldaerdwghakdyveamwlml
qqeqprdfcvatgekhsvrefvekafacigqtvewkgergtveehgvvdgvvrvrvdpry
frptevdqllgdptlaetvlgwkrkvsfeelvrgmvegdiellqs

SCOPe Domain Coordinates for d5uzha_:

Click to download the PDB-style file with coordinates for d5uzha_.
(The format of our PDB-style files is described here.)

Timeline for d5uzha_:

  • d5uzha_ appears in periodic updates to SCOPe 2.06 starting on 2017-04-06