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Lineage for d5v24a_ (5v24 A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2199100Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2199101Protein automated matches [190417] (25 species)
    not a true protein
  7. 2199241Species Human (Homo sapiens) [TaxId:9606] [187294] (778 PDB entries)
  8. 2289210Domain d5v24a_: 5v24 A: [332511]
    automated match to d2clqa_
    complexed with 8v7

Details for d5v24a_

PDB Entry: 5v24 (more details), 2.5 Å

PDB Description: structure-based drug design of novel ask1 inhibitors using a fully integrated lead optimization strategy
PDB Compounds: (A:) mitogen-activated protein kinase kinase kinase 5

SCOPe Domain Sequences for d5v24a_:

Sequence, based on SEQRES records: (download)

>d5v24a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsrysqplheeialhk
hlkhknivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileg
lkylhdnqivhrdikgdnvlintysgvlkisdfgtskrlaginpctetftgtlqymapei
idkgprgygkaadiwslgctiiematgkppfyelgepqaamfkvgmfkvhpeipesmsae
akafilkcfepdpdkracandllvdeflk

Sequence, based on observed residues (ATOM records): (download)

>d5v24a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
leydyeydengdrvvlgkgtygivyagrdlsnqvriaikeiperdsplheeialhkhlkh
knivqylgsfsengfikifmeqvpggslsallrskwgplkdneqtigfytkqileglkyl
hdnqivhrdikgdnvlintysgvlkisdfgtskrlftgtlqymapeiidygkaadiwslg
ctiiematgkppfyeepqaamfkvgmfkvhpeipesmsaeakafilkcfepdpdkracan
dllvdeflk

SCOPe Domain Coordinates for d5v24a_:

Click to download the PDB-style file with coordinates for d5v24a_.
(The format of our PDB-style files is described here.)

Timeline for d5v24a_:

  • d5v24a_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-30