SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5mu8a_ (5mu8 A:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2041369Fold b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  4. 2041370Superfamily b.22.1: TNF-like [49842] (2 families) (S)
  5. 2041371Family b.22.1.1: TNF-like [49843] (15 protein domains)
  6. 2041568Protein Tumor necrosis factor (TNF) [49848] (2 species)
  7. 2041569Species Human (Homo sapiens) [TaxId:9606] [49849] (15 PDB entries)
  8. 2289201Domain d5mu8a_: 5mu8 A: [332502]
    automated match to d1a8ma_
    complexed with jni

Details for d5mu8a_

PDB Entry: 5mu8 (more details), 3 Å

PDB Description: human tnf-alpha in complex with jnj525
PDB Compounds: (A:) Tumor necrosis factor

SCOPe Domain Sequences for d5mu8a_:

Sequence, based on SEQRES records: (download)

>d5mu8a_ b.22.1.1 (A:) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
sdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqg
cpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlek
gdrlsaeinrpdyldfaesgqvyfgiial

Sequence, based on observed residues (ATOM records): (download)

>d5mu8a_ b.22.1.1 (A:) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
sdkpvahvvanpqaegqlqwlnallangvelrdnqlvvpseglyliysqvlfkgqgcpst
hvllthtisriavsyqtkvnllsaikspcqreteakpwyepiylggvfqlekgdrlsaei
nrpdyldfaesgqvyfgiial

SCOPe Domain Coordinates for d5mu8a_:

Click to download the PDB-style file with coordinates for d5mu8a_.
(The format of our PDB-style files is described here.)

Timeline for d5mu8a_:

  • d5mu8a_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-30