SCOPe 2.06: Domain d5isoe2: 5iso E:183-324

Lineage for d5isoe2 (5iso E:183-324)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.37: CBS-domain pair [54630] (1 superfamily)
   duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a

4. Superfamily d.37.1: CBS-domain pair [54631] (2 families)

5. Family d.37.1.1: CBS-domain pair [54632] (21 proteins)
   Pfam PF00571; pairs of CBS domains dimerize to form a stable globular domain, a.k.a. Bateman domain

6. Protein 5'-AMP-activated protein kinase subunit gamma-1, AMPKg [160176] (1 species)

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [160177] (10 PDB entries)
   Uniprot P80385 182-326! Uniprot P80385 23-181

8. Domain d5isoe2: 5iso E:183-324 [332468]
   automated match to d2v8qe1
   complexed with 992, amp, stu

Details for d5isoe2

PDB Entry: 5iso, 2.63 Å

PDB Description: structure of full length human ampk (non-phosphorylated at t-loop) in complex with a small molecule activator, a benzimidazole derivative (991)

PDB Compounds: (E:) 5'-amp-activated protein kinase subunit gamma-1

SCOPe Domain Sequences for d5isoe2:

Sequence; same for both SEQRES and ATOM records:

>d5isoe2 d.37.1.1 (E:183-324) 5'-AMP-activated protein kinase subunit gamma-1, AMPKg {Norway rat (Rattus norvegicus) [TaxId: 10116]}
fpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiys
kfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetletiinrlveaevhrlvv
vdendvvkgivslsdilqalvl

Timeline for d5isoe2:

• d5isoe2 is new in SCOPe 2.06-stable
  
• d5isoe2 appears in SCOPe 2.07
  
• d5isoe2 appears in the current release, SCOPe 2.08