Lineage for d5mw3b_ (5mw3 B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2129295Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 2129296Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families) (S)
  5. 2130146Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 protein domains)
  6. 2130154Protein automated matches [191247] (1 species)
    not a true protein
  7. 2130155Species Human (Homo sapiens) [TaxId:9606] [189737] (27 PDB entries)
  8. 2288516Domain d5mw3b_: 5mw3 B: [331817]
    automated match to d4hraa_
    complexed with 5jj, 5jt, tla

Details for d5mw3b_

PDB Entry: 5mw3 (more details), 2.09 Å

PDB Description: crystal structure of dot1l in complex with inhibitor cpd1 [n6-(2,6- dichlorophenyl)-n6-(pent-2-yn-1-yl)quinoline-4,6-diamine] and inhibitor cpd2 [(r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3- amine]
PDB Compounds: (B:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d5mw3b_:

Sequence, based on SEQRES records: (download)

>d5mw3b_ c.66.1.31 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpe
klnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhy
gvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnf
afgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsv
swtgkpvsyylhtidrtilenyfsslkn

Sequence, based on observed residues (ATOM records): (download)

>d5mw3b_ c.66.1.31 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgtlntrpstgllrhilqqvynhsvtdpeklnny
epfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygveka
dipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpe
vdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkvswtgkpv
syylhtidrtilenyfsslkn

SCOPe Domain Coordinates for d5mw3b_:

Click to download the PDB-style file with coordinates for d5mw3b_.
(The format of our PDB-style files is described here.)

Timeline for d5mw3b_:

  • d5mw3b_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-23