SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5mw4b_ (5mw4 B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2129295Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 2129296Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families) (S)
  5. 2130146Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 protein domains)
  6. 2130154Protein automated matches [191247] (1 species)
    not a true protein
  7. 2130155Species Human (Homo sapiens) [TaxId:9606] [189737] (27 PDB entries)
  8. 2288459Domain d5mw4b_: 5mw4 B: [331760]
    automated match to d4hraa_
    complexed with 5ju, so4

Details for d5mw4b_

PDB Entry: 5mw4 (more details), 2.19 Å

PDB Description: crystal structure of dot1l in complex with inhibitor cpd7 [n-(3-(((r)- 1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)(methyl)amino) propyl)-2-(3-(2-chloro-3-(2-methylpyridin-3-yl)benzo[b]thiophen-5- yl)ureido)acetamide]
PDB Compounds: (B:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d5mw4b_:

Sequence, based on SEQRES records: (download)

>d5mw4b_ c.66.1.31 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpe
klnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhy
gvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnf
afgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsv
swtgkpvsyylhtidrtilenyfsslkn

Sequence, based on observed residues (ATOM records): (download)

>d5mw4b_ c.66.1.31 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgtntrpstgllrhilqqvynhsvtdpeklgets
fdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipakyaetmdr
efrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhqlkerfanm
keggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvswtgkpvsyylhtidrt
ilenyfsslkn

SCOPe Domain Coordinates for d5mw4b_:

Click to download the PDB-style file with coordinates for d5mw4b_.
(The format of our PDB-style files is described here.)

Timeline for d5mw4b_:

  • d5mw4b_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-23