SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5uawa1 (5uaw A:2-164)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2094257Family c.2.1.0: automated matches [191313] (1 protein)
    not a true family
  6. 2094258Protein automated matches [190069] (226 species)
    not a true protein
  7. 2095073Species Human (Homo sapiens) [TaxId:9606] [186944] (46 PDB entries)
  8. 2288167Domain d5uawa1: 5uaw A:2-164 [331468]
    Other proteins in same PDB: d5uawa2, d5uawb2, d5uawb3, d5uawc2, d5uawd2, d5uawd3, d5uawe2, d5uawe3
    automated match to d2izza1
    complexed with so4

Details for d5uawa1

PDB Entry: 5uaw (more details), 1.85 Å

PDB Description: structure of apo human pycr-1 crystallized in space group p21212
PDB Compounds: (A:) Pyrroline-5-carboxylate reductase 1, mitochondrial

SCOPe Domain Sequences for d5uawa1:

Sequence, based on SEQRES records: (download)

>d5uawa1 c.2.1.0 (A:2-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnketvq
hsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvircm
tntpvvvregatvyatgthaqvedgrlmeqllssvgfctevee

Sequence, based on observed residues (ATOM records): (download)

>d5uawa1 c.2.1.0 (A:2-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svgfigagqlafalakgftaagvlaahkimasalrkmgvkltphnketvqhsdvlflavk
phiipfildeigadiedrhivvscaagvtissiekklsafrpaprvircmtntpvvvreg
atvyatgthaqvedgrlmeqllssvgfctevee

SCOPe Domain Coordinates for d5uawa1:

Click to download the PDB-style file with coordinates for d5uawa1.
(The format of our PDB-style files is described here.)

Timeline for d5uawa1:

  • d5uawa1 appears in periodic updates to SCOPe 2.06 starting on 2017-03-16