SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5uaue1 (5uau E:1-164)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2094257Family c.2.1.0: automated matches [191313] (1 protein)
    not a true family
  6. 2094258Protein automated matches [190069] (230 species)
    not a true protein
  7. 2095073Species Human (Homo sapiens) [TaxId:9606] [186944] (46 PDB entries)
  8. 2288125Domain d5uaue1: 5uau E:1-164 [331426]
    Other proteins in same PDB: d5uaua2, d5uaub2, d5uaub3, d5uauc2, d5uauc3, d5uaud2, d5uaue2
    automated match to d2izza1
    complexed with pro, so4

Details for d5uaue1

PDB Entry: 5uau (more details), 1.9 Å

PDB Description: structure of human pycr-1 complexed with proline
PDB Compounds: (E:) Pyrroline-5-carboxylate reductase 1, mitochondrial

SCOPe Domain Sequences for d5uaue1:

Sequence, based on SEQRES records: (download)

>d5uaue1 c.2.1.0 (E:1-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}
msvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnketv
qhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvirc
mtntpvvvregatvyatgthaqvedgrlmeqllssvgfctevee

Sequence, based on observed residues (ATOM records): (download)

>d5uaue1 c.2.1.0 (E:1-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}
msvgfigagqlafalakgftaagvlaahkimasspdmlrkmgvkltphnketvqhsdvlf
lavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvircmtntpvv
vregatvyatgthaqvedgrlmeqllssvgfctevee

SCOPe Domain Coordinates for d5uaue1:

Click to download the PDB-style file with coordinates for d5uaue1.
(The format of our PDB-style files is described here.)

Timeline for d5uaue1:

  • d5uaue1 appears in periodic updates to SCOPe 2.06 starting on 2017-03-16