SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d5u6ia_ (5u6i A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195690Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2198144Protein automated matches [190091] (14 species)
    not a true protein
  7. 2198237Species Human (Homo sapiens) [TaxId:9606] [188447] (583 PDB entries)
  8. 2288121Domain d5u6ia_: 5u6i A: [331422]
    automated match to d3sa0a_
    complexed with 81y, so4

Details for d5u6ia_

PDB Entry: 5u6i (more details), 1.69 Å

PDB Description: discovery of mli-2, an orally available and selective lrrk2 inhibitor that reduces brain kinase activity
PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d5u6ia_:

Sequence, based on SEQRES records: (download)

>d5u6ia_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlreikillr
frheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrgl
kyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyrape
imlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciin
lkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyy
dpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Sequence, based on observed residues (ATOM records): (download)

>d5u6ia_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vfdvgprytnlsyigegagmvcsaydnlnkvrvaikkispfehqtycqrtlreikillrf
rheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrglk
yihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyrapei
mlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinl
karnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyyd
psdepiaeapfkfdmelddlpkeklkelifeetarfqpg

SCOPe Domain Coordinates for d5u6ia_:

Click to download the PDB-style file with coordinates for d5u6ia_.
(The format of our PDB-style files is described here.)

Timeline for d5u6ia_:

  • d5u6ia_ appears in periodic updates to SCOPe 2.06 starting on 2017-03-16