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Lineage for d5jhba3 (5jhb A:726-1091)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195572Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)
  6. 2195573Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)
  7. 2195574Species Human (Homo sapiens) [TaxId:9606] [56174] (61 PDB entries)
  8. 2287772Domain d5jhba3: 5jhb A:726-1091 [331073]
    Other proteins in same PDB: d5jhba1, d5jhba2
    automated match to d1he8a4
    complexed with 6k5, so4

Details for d5jhba3

PDB Entry: 5jhb (more details), 2.48 Å

PDB Description: structure of phosphoinositide 3-kinase gamma (pi3k) bound to the potent inhibitor pikin3
PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d5jhba3:

Sequence, based on SEQRES records: (download)

>d5jhba3 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlv

Sequence, based on observed residues (ATOM records): (download)

>d5jhba3 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsassqvisqlkqklenlqlpesfrvpydpglka
galaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimes
iwetesldlcllpygcistgdkigmieivkdattiakiqqsfkdevlnhwlkekspteek
fqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghiervpfvltpdfl
fvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmptskedieyirda
ltvgkneedakkyfldqievcrdkgwtvqfnwflhlv

SCOPe Domain Coordinates for d5jhba3:

Click to download the PDB-style file with coordinates for d5jhba3.
(The format of our PDB-style files is described here.)

Timeline for d5jhba3:

  • d5jhba3 appears in periodic updates to SCOPe 2.06 starting on 2017-03-16