SCOPe 2.08: Domain d5jhba3: 5jhb A:726-1091

Lineage for d5jhba3 (5jhb A:726-1091)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d5jhba3: 5jhb A:726-1091 [331073]
   Other proteins in same PDB: d5jhba1, d5jhba2, d5jhba4
   automated match to d1he8a4
   complexed with 6k5, so4

Details for d5jhba3

PDB Entry: 5jhb, 2.48 Å

PDB Description: structure of phosphoinositide 3-kinase gamma (pi3k) bound to the potent inhibitor pikin3

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d5jhba3:

Sequence, based on SEQRES records:

>d5jhba3 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlv

Sequence, based on observed residues (ATOM records):

>d5jhba3 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsassqvisqlkqklenlqlpesfrvpydpglka
galaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimes
iwetesldlcllpygcistgdkigmieivkdattiakiqqsfkdevlnhwlkekspteek
fqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghiervpfvltpdfl
fvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmptskedieyirda
ltvgkneedakkyfldqievcrdkgwtvqfnwflhlv

Timeline for d5jhba3:

• d5jhba3 first appeared in SCOPe 2.06
  
• d5jhba3 appears in SCOPe 2.07