SCOPe 2.08: Domain d5t18a1: 5t18 A:396-658

Lineage for d5t18a1 (5t18 A:396-658)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d5t18a1: 5t18 A:396-658 [330939]
   Other proteins in same PDB: d5t18a2
   automated match to d4z3va_
   complexed with 73t

Details for d5t18a1

PDB Entry: 5t18, 1.5 Å

PDB Description: crystal structure of bruton agammabulinemia tyrosine kinase complexed with bms-986142 aka (2s)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo- 1,2,3,4-tetrahydroquinazolin-3-yl)-2-methylphenyl]-2-(2- hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide

PDB Compounds: (A:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d5t18a1:

Sequence, based on SEQRES records:

>d5t18a1 d.144.1.7 (A:396-658) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwh
ekaderptfkillsnildvmdee

Sequence, based on observed residues (ATOM records):

>d5t18a1 d.144.1.7 (A:396-658) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylrefqtqqllemckdvceameyleskqflh
rdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfssksd
iwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwhekad
erptfkillsnildvmdee

Timeline for d5t18a1:

• d5t18a1 first appeared in SCOPe 2.06
  
• d5t18a1 appears in SCOPe 2.07