SCOPe 2.06: Domain d5muta_: 5mut A:

Lineage for d5muta_ (5mut A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (43 PDB entries)

8. Domain d5muta_: 5mut A: [330808]
   automated match to d3kvma_
   complexed with act, cl, fmn, hyt, oro

Details for d5muta_

PDB Entry: 5mut, 1.75 Å

PDB Description: crystal structure of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds

PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d5muta_:

Sequence, based on SEQRES records:

>d5muta_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
tgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnp
vgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfns
hglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvv
nvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasv
vkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpii
gvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaig
adhrr

Sequence, based on observed residues (ATOM records):

>d5muta_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
tgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgi
aagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgl
svvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvg
kaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtntt
vsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdaleki
ragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

Timeline for d5muta_:

• d5muta_ is new in SCOPe 2.06-stable
  
• d5muta_ appears in SCOPe 2.07
  
• d5muta_ appears in the current release, SCOPe 2.08